System-wide Analyses of Transcriptional Control in Animals

Monday, October 26, 2015
11:00 am - 12:00 pm, Gonda Center - First Floor Conference Room, 1357

Human Genetics Seminar Series

See below for additional information.

Admission

Free and open to the public.

Contact

Human Genetics
(310) 267-2487
cmcdonald@mednet.ucla.edu

Website

http://www.genetics.ucla.edu/speakers/

Additional Information

Dr. Jessica Li is hosting Mark Biggin, Ph.D. Staff Scientist, Genomics Division Lawrence Berkeley National Laboratory.

In vivo, animal transcription factors each show a quantitative continuum of functional, quasi-functional, and nonfunctional DNA binding across thousands of genomic regions lying close to most genes. We are using computational analyses and experimental methods to elucidate the biochemical mechanisms that produce these patterns of DNA binding and how these messy combinations of transcription factors cooperate to generate precise spatial and temporal gene expression.

Over the last decade, many researchers have suggested that post transcriptional regulation plays a larger role than transcriptional control in determining differences in protein expression between genes. We have critically reexamined this work and shown that once measurement error in the data is taken into account, transcriptional control is the dominant step, consistent with the classic view from decades past.

Light snack will be provided.

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