“ImmunoPET for molecular imaging in oncology and beyond:"

Thursday, November 15, 2012
12:00 am - 1:00 am, Health Sciences Ctr. - Room 73-105

Anna Wu, Ph.D

See below for additional information.

Admission

Free and open to the public.

Contact

Jonsson Comprehensive Cancer Center
(310) 825-5268
ajun@mednet.ucla.edu

Additional Information

“ImmunoPET for molecular imaging in oncology and beyond: Towards imagining immune cell subsets and immune responses”

Presented by: Anna Wu, Ph.D., Professor, Department of Molecular and Medical Pharmacology, Department of Pathology and Laboratory Medicine, Director of the JCCC Cancer Molecular Imaging Program Area

Dr. Anna Wu's research focuses on understanding and using molecular recognition (protein-protein, nucleic acid-nucleic acid and protein-nucleic acid) to distinguish tumor cells from normal cells and to develop practical applications in oncology - diagnostic or therapeutic.

Her recent work has focused on genetic engineering of antibodies to provide optimal agents for delivery of radionuclides to tumor cells. Monoclonal antibodies specific for human tumor antigens have been re-engineered to reduce immunogenicity (by chimerization or humanization), and engineered fragments with improved pharmacokinetic properties have been produced. Biological therapies based on engineered antibodies are also under investigation, including retargeting T-cells using antibody-T-cell receptor fusion proteins, and intracellular expression of single-chain antibodies.

New biological probes for imaging are being developed. Antibodies, peptides and oligonucleotides tagged with positron-emitting isotopes can provide highly specific tools for examining gene expression and function in cells and tissues, and ultimately, patients.

Light lunch served.

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