Causes and Consequences of Human Genomic Variation
Monday, March 13, 2017
11:00 am - 12:00 pm, Neuroscience Research Bldg. - Auditorium - Room 132
See below for additional information.
Free and open to the public.
Jazlyn Mooney is hosting Sohini Ramachandran, PhD, Manning Assistant Professor, Ecology and Evolutionary Biology, Brown University.
Determining the genomic elements underlying adaptive evolution and diseases in a species is essential for connecting genetic variation to phenotypes and fitness, but current statistical methods overlook the confounding effect population histories have on the identification and localization of adaptive and disease-associated mutations. Dr. Ramachandran discuss two methods developed in her laboratory that
- model the complex interaction between various modes of selection and population histories; and
- accurately identify and localize mutations, genes, and pathways underlying adaptive traits and disease for further experimental validation.
These methods can be extended and applied to existing and emerging genome-wide polymorphism and next-generation sequencing datasets for humans and a range of other organisms. The lab's goal is to yield new insight into the interaction between selection and dynamic population histories in generating human genetic diversity and the human phenotype.
Light snack will be provided.