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Cas9-mediated Whole-cell Engineering

Tuesday, January 17, 2017
11:00 am - 12:00 pm, Gonda Center - First Floor Conference Room, 1357

Human Genetics Seminar Series

See below for additional information.

Admission

Free and open to the public.

Contact

Department of Human Genetics
(310) 267-2487
cmcdonald@mednet.ucla.edu

Website

http://www.genetics.ucla.edu/speakers/

Additional Information

Dr. Marc Suchard is hosting Alejandro (Alex) Chavez, PhD. Postdoctoral Fellow Wyss Institute at Harvard University.

Dr. Chavez will present a series of improvements to the RNA-guided endonuclease Cas9 that drastically enhance its ability to induce potent gene expression at genome-wide scales. Furthermore, Dr. Chavez will provide simple gRNA design principles that allow users to regulate Cas9 nuclease activity and by doing so, utilize a single Cas9 protein to simultaneously perform targeted gene activation, repression and cutting. Finally, in more recent work his lab has developed a generalizable method for increasing Cas9 specificity, enabling it to select between two alleles that differ by a single nucleotide polymorphism.

Using these tools, he will demonstrate their ability to activate a series of endogenous loci, reprogram iPS cells into neurons, regulate complex transcriptional cascades, and prevent the emergence of undesired point mutations within a population of cells.

Light snack will be provided.

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